"Irregardless" doesn't bother me much - I just avoid using it because "regardless" is the same thing.

The new TV newcaster words that do bother me (and you hear them all the time) are "horrendous" and "horrific".

Those are just made-up combinations of "horrible" with "tremendous" and "terrific". How ignorant.

Whenever you hear those words, it's Geraldo Rivera-type breathless sensational reporting - and I hate that crap.